About this material
Sphingosine is a Skin-identical lipid / phospholipid supplied by MakeYourSkin as powder / lipid dispersion / oil for professional cosmetic formulation. Used worldwide across mainstream cosmetic formulation, it is valued for barrier lipid replenishment, conditioning.
What is Sphingosine?
Sphingosine is supplied under the INCI / technical name Sphingosine and carries CAS number 123-78-4.
It belongs to the Skin-identical lipid / phospholipid group and is available from plant, biotech or animal-free grades available routes depending on the grade ordered. The material reaches you as powder / lipid dispersion / oil. It is an established cosmetic raw material with mature supply and well-understood formulation behaviour.
Key Properties & Benefits
- Barrier lipid replenishment
- Conditioning
- Supplied cosmetic grade with a Certificate of Analysis for every batch.
Uses & Applications
Sphingosine is used in barrier creams, ceramide moisturisers, post-procedure recovery products, sensitive-skin lotions, cleansing balms and overnight masks.
Typical applications from the catalogue record: Barrier creams, serums, scalp.
In leave-on skincare it is normally dosed into a serum, ampoule or moisturiser where contact time is long enough for the claim to hold up. In rinse-off formats it is used at a lower level for label presence and sensory contribution rather than measurable performance.
Handling note: Add to the oil phase and protect from prolonged heat and air exposure.
How to Use — Recommended Use Level
| Typical use level | 1–15% |
|---|---|
| Recommended pH | any |
| Addition phase | Oil phase |
| Solubility | Oil-soluble. Add to the oil phase; will not disperse in water without a solubiliser or emulsifier. |
General rule: always begin at the lower end of the range, confirm the level against the supplier technical data sheet, and validate stability, pH, colour, odour and preservative efficacy on the finished formulation before scaling up.
Technical Specification
| INCI / Technical Name | Sphingosine |
|---|---|
| CAS Number | 123-78-4 |
| Ingredient Family | Skin-identical lipid / phospholipid |
| Primary Cosmetic Functions | Barrier lipid replenishment; conditioning |
| Typical Applications | Barrier creams, serums, scalp |
| Source / Feedstock | Plant / biotech / animal-free grades available |
| Origin / Tradition | Global |
| Typical Bulk Form | Powder / lipid dispersion / oil |
| Appearance | White to off-white crystalline or amorphous powder (botanical grades may be coloured) |
| Solubility | Oil Soluble |
| Market Status | Established |
| Catalogue Range | Core Range |
| Storage | Store in a cool, dark place in a well-filled, tightly closed container. Minimise headspace and light exposure to limit oxidation; refrigeration extends shelf life for polyunsaturated oils. |
| Shelf Life | 12–24 months from manufacture in unopened original packaging |
| Vendor | MakeYourSkin |
| MYS Catalogue Code | COS-A00169 |
Regulatory Note
Supplier diligence required: Source and exact composition verification.
Sold as a cosmetic raw material for professional formulation. A published INCI name does not by itself authorise use: the buyer is responsible for confirming permitted status, maximum concentration, restrictions by product type, labelling and claim rules in every market the finished product is sold in. In India, cosmetics fall under the Drugs and Cosmetics Act 1940 and the Cosmetics Rules 2020 administered by CDSCO, with BIS standards (including IS 4707 Part 2) listing restricted substances. The EU applies Regulation (EC) No 1223/2009 and its Annexes; the United States applies the FD&C Act as amended by MoCRA; Korea, Japan and China operate their own positive lists and functional-cosmetic frameworks. Every finished product needs its own safety assessment.
Reference: Regulatory / scientific reference
Documentation Supplied
- Certificate of Analysis (CoA) for the batch supplied
- Safety Data Sheet (SDS / MSDS) in the current GHS format
- Technical Data Sheet (TDS) with specification, solubility and handling guidance
- INCI declaration and, where assigned, CAS / EINECS numbers
- Non-GMO statement on request
- Vegan / animal-origin declaration on request
- Halal and Kosher certification on request where the supplier holds it
- Heavy-metal and microbiological test data on request
Available Pack Sizes
This is a high-value material, so it is supplied on our small-pack ladder: 10 g, 50 g, 100 g and 1 Kg. Larger quantities are quoted on request — contact the MakeYourSkin sales desk for availability, lead time and a firm price.
| 10 g | Bench trial, stability screening and claim work |
|---|---|
| 50 g | Pilot batches and small production runs |
| 100 g | Regular production for premium formulas |
| 1 Kg | Full production quantity; larger volumes quoted on request |
Disclaimer & Caution in Use
For external cosmetic use in professionally formulated products only. This is a concentrated raw material, not a finished cosmetic, and it is not intended for undiluted application to skin, for ingestion, or for any medicinal purpose. Wear gloves and eye protection when handling, avoid raising dust with powders, and keep out of reach of children and pets. Always run a patch test on the finished formulation, and validate stability, compatibility, pH and preservative efficacy before sale. Information supplied is offered in good faith as formulation guidance and does not constitute a safety assessment, a regulatory approval or a medical claim.
Fine powder — avoid generating and inhaling dust. Use local exhaust ventilation or a suitable respirator when weighing, and wet the powder into the formulation phase rather than dry-blending in open air.
Specification
| INCI NAME | Sphingosine |
|---|---|
| CAS NUMBER | 123-78-4 |
| FAMILY | Skin-identical lipid / phospholipid |
| ORIGIN | Global — Plant / biotech / animal-free grades available |
| SUPPLY FORM | Powder / lipid dispersion / oil |
| SOLUBILITY | Oil Soluble — Oil-soluble. Add to the oil phase; will not disperse in water without a solubiliser or emulsifier. |
| TYPICAL USE LEVEL | 1–15% |
| pH RANGE | any |
| ADD AT | Oil phase |
| FUNCTIONS | Barrier lipid replenishment; conditioning |
| USED IN | Barrier creams, serums, scalp |
| STORAGE | Store in a cool, dark place in a well-filled, tightly closed container. Minimise headspace and light exposure to limit oxidation; refrigeration extends shelf life for polyunsaturated oils. |
| PACK SIZES | 10 g to 1 Kg |
| REGULATORY | Source and exact composition verification |
How to work with it
The specification's Add at row is the one to read first. Water-phase materials added to a hot oil phase are the most common reason a batch separates.
Measure the finished product, not the premix. Outside the range the activity drops away and, for some materials, the degradation route is what causes complaints.
Then work up through stability and compatibility testing. Higher is not better, and the destination market's limit may sit below your formulation ceiling.