About this material
PDRN (salmon-derived polydeoxyribonucleotide) (Sodium DNA) is nucleic acid active supplied by MakeYourSkin as 1000-5000 ppm aqueous solution or powder for professional cosmetic formulation. Sourced in the Korea tradition. It is valued for adenosine a2a receptor signalling, repair, anti-inflammatory, hydration.
What is PDRN (salmon-derived polydeoxyribonucleotide)?
PDRN (salmon-derived polydeoxyribonucleotide) is supplied under the INCI / technical name Sodium DNA.
It belongs to the Nucleic acid active group. The material reaches you as 1000-5000 ppm aqueous solution or powder. Salmon sperm DNA; the headline K-beauty active of 2025-26. Sourcing and molecular-weight range matter more than the INCI, which is shared with unrelated DNA grades.
Key Properties & Benefits
- Adenosine A2A receptor signalling
- Repair
- Anti-inflammatory
- Hydration
- Supplied with full documentation — CoA, SDS and specification
Uses & Applications
Typically formulated into post-procedure ampoules, repair serums, k-beauty creams.
How to Use — Recommended Use Level
Typical use level: 0.1-5% of a 5000 ppm solution. Add at the water phase. Water-soluble. Disperse into the water phase with stirring; avoid prolonged high heat where the material is heat-sensitive.
Always trial the material in your own base at small scale before scaling up. Use levels are formulation starting points, not approvals.
Technical Specification
- INCI name: Sodium DNA
- Ingredient family: Nucleic acid active
- Origin / tradition: Korea
- Typical form: 1000-5000 ppm aqueous solution or powder
- Solubility: Water Soluble
- Typical use level: 0.1-5% of a 5000 ppm solution
- pH range: 4.5–7.0
- Addition phase: Water phase
- Pack sizes: 1 g; 5 g; 10 g; 50 g; bulk on request
Technical Notes
Salmon sperm DNA; the headline K-beauty active of 2025-26. Sourcing and molecular-weight range matter more than the INCI, which is shared with unrelated DNA grades.
Regulatory Note
Sold as a cosmetic raw material for professional formulation. A published INCI name does not by itself authorise use: the buyer is responsible for confirming permitted status, maximum concentration, restrictions by product type, labelling and claim rules in every market the finished product is sold in. In India, cosmetics fall under the Drugs and Cosmetics Act 1940 and the Cosmetics Rules 2020 administered by CDSCO, with BIS standards (including IS 4707 Part 2) listing restricted substances. The EU applies Regulation (EC) No 1223/2009 and its Annexes; the United States applies the FD&C Act as amended by MoCRA; Korea, Japan and China operate their own positive lists and functional-cosmetic frameworks. Every finished product needs its own safety assessment.
Documentation Supplied
Certificate of Analysis (CoA) for the batch supplied; Safety Data Sheet (SDS / MSDS) in the current GHS format; INCI and technical specification sheet; allergen, GMO and origin statements on request; vegan, halal and kosher declarations where the supply chain supports them.
Available Pack Sizes
1 g; 5 g; 10 g; 50 g; bulk on request
Disclaimer & Caution in Use
For external cosmetic use in professionally formulated products only. This is a concentrated raw material, not a finished product: do not apply it undiluted to skin or hair. Wear suitable gloves and eye protection when handling, weigh in a ventilated area, and keep out of reach of children. Patch test every finished formulation. Not for ingestion unless a food or oral-care grade is specifically supplied and documented as such. Seek medical advice in case of eye contact, ingestion or an adverse reaction. Low-pH material. Confirm the finished-product pH and provide the sun-protection and irritation warnings your market requires.
Specification
| INCI NAME | Sodium DNA |
|---|---|
| CAS NUMBER | Not assigned |
| FAMILY | Nucleic acid active |
| ORIGIN | Korea |
| SUPPLY FORM | 1000-5000 ppm aqueous solution or powder |
| SOLUBILITY | Water-soluble. Disperse into the water phase with stirring; avoid prolonged high heat where the material is heat-sensitive. |
| TYPICAL USE LEVEL | 0.1-5% of a 5000 ppm solution |
| pH RANGE | 4.5–7.0 |
| ADD AT | Water phase |
| FUNCTIONS | Adenosine A2A receptor signalling, repair, anti-inflammatory, hydration |
| USED IN | Post-procedure ampoules, repair serums, K-beauty creams |
| STORAGE | Store at 15–25 °C in a tightly closed container, protected from light. Do not freeze. Some biological materials are supplied chilled — follow the batch documentation. |
| PACK SIZES | 1 g; 5 g; 10 g; 50 g; bulk on request |
| LEAD TIME | 10–16 days |
| REGULATORY | Sold as a cosmetic raw material for professional formulation. A published INCI name does not by itself authorise use: the buyer is responsible for confirming permitted status, maximum concentration, restrictions by product type, labelling and claim rules in every market the finished product is sold in. In India, cosmetics fall under the Drugs and Cosmetics Act 1940 and the Cosmetics Rules 2020 administered by CDSCO, with BIS standards (including IS 4707 Part 2) listing restricted substances. The EU applies Regulation (EC) No 1223/2009 and its Annexes; the United States applies the FD&C Act as amended by MoCRA; Korea, Japan and China operate their own positive lists and functional-cosmetic frameworks. Every finished product needs its own safety assessment. |
How to work with it
The specification's Add at row is the one to read first. Water-phase materials added to a hot oil phase are the most common reason a batch separates.
Measure the finished product, not the premix. Outside the range the activity drops away and, for some materials, the degradation route is what causes complaints.
Then work up through stability and compatibility testing. Higher is not better, and the destination market's limit may sit below your formulation ceiling.