About this material
Argireline-Type Hexapeptide Solution (Acetyl Hexapeptide-8 (and) Water) is a Neurocosmetic peptide solution supplied by MakeYourSkin as a liquid for professional cosmetic formulation. Used worldwide across mainstream cosmetic formulation, it is valued for expression-line positioning.
What is Argireline-Type Hexapeptide Solution?
Argireline-Type Hexapeptide Solution is supplied under the INCI / technical name Acetyl Hexapeptide-8 (and) Water and carries CAS number 616204-22-9.
It belongs to the Neurocosmetic peptide solution group and is derived from synthetic peptide. The material reaches you as a liquid. It is an established cosmetic raw material with mature supply and well-understood formulation behaviour.
Key Properties & Benefits
- Expression-line positioning
- Supplied as a standardised solution so the finished-product dose can be calculated accurately.
Uses & Applications
Argireline-Type Hexapeptide Solution is used in ampoules, eye creams, targeted anti-ageing serums, scalp treatments and lip treatments.
Typical applications from the catalogue record: Eye creams, ampoules, primers.
In leave-on skincare it is normally dosed into a serum, ampoule or moisturiser where contact time is long enough for the claim to hold up. In rinse-off formats it is used at a lower level for label presence and sensory contribution rather than measurable performance.
Handling note: Supplied ready to dose; check the active content on the technical data sheet, because liquid grades are usually dilutions.
How to Use — Recommended Use Level
| Typical use level | 2–10% of the supplied solution (supplier-specified; active peptide is usually present at ppm level) |
|---|---|
| Recommended pH | 4.5–7.0 |
| Addition phase | Water phase, cool-down below 40 °C |
| Solubility | Water-soluble. Disperse into the water phase with stirring; avoid prolonged high heat where the material is heat-sensitive. |
General rule: always begin at the lower end of the range, confirm the level against the supplier technical data sheet, and validate stability, pH, colour, odour and preservative efficacy on the finished formulation before scaling up.
Technical Specification
| INCI / Technical Name | Acetyl Hexapeptide-8 (and) Water |
|---|---|
| CAS Number | 616204-22-9 |
| Ingredient Family | Neurocosmetic peptide solution |
| Primary Cosmetic Functions | Expression-line positioning |
| Typical Applications | Eye creams, ampoules, primers |
| Source / Feedstock | Synthetic peptide |
| Origin / Tradition | Global |
| Typical Bulk Form | Liquid |
| Appearance | Clear to amber liquid depending on grade |
| Solubility | Water Soluble |
| Market Status | Established |
| Catalogue Range | Core Range |
| Storage | Cold-chain material. Store refrigerated at 2–8 °C, protect from light and return to refrigeration immediately after use. Do not freeze unless the technical data sheet says otherwise. |
| Shelf Life | 24–36 months from manufacture in unopened original packaging; see the Certificate of Analysis |
| Vendor | MakeYourSkin |
| MYS Catalogue Code | MYS-N00234 |
Technical Notes
Usually supplied as a 5–10% solution; dose on the solution, not the peptide.
Regulatory Note
Confirm the exact INCI, the supplied concentration of active peptide, the carrier and preservative system, and the purity and residual-solvent profile. Peptide claim substantiation must match cosmetic claim rules; efficacy data generated in vitro or at levels above the finished-product concentration does not support a strong finished-product claim.
Supplier diligence required: Supplier composition / claims / jurisdiction review.
Sold as a cosmetic raw material for professional formulation. A published INCI name does not by itself authorise use: the buyer is responsible for confirming permitted status, maximum concentration, restrictions by product type, labelling and claim rules in every market the finished product is sold in. In India, cosmetics fall under the Drugs and Cosmetics Act 1940 and the Cosmetics Rules 2020 administered by CDSCO, with BIS standards (including IS 4707 Part 2) listing restricted substances. The EU applies Regulation (EC) No 1223/2009 and its Annexes; the United States applies the FD&C Act as amended by MoCRA; Korea, Japan and China operate their own positive lists and functional-cosmetic frameworks. Every finished product needs its own safety assessment.
Reference: Regulatory / scientific reference
Documentation Supplied
- Certificate of Analysis (CoA) for the batch supplied
- Safety Data Sheet (SDS / MSDS) in the current GHS format
- Technical Data Sheet (TDS) with specification, solubility and handling guidance
- INCI declaration and, where assigned, CAS / EINECS numbers
- Peptide purity, sequence confirmation and residual-solvent data
- Non-GMO statement on request
- Vegan / animal-origin declaration on request
- Halal and Kosher certification on request where the supplier holds it
- Heavy-metal and microbiological test data on request
Available Pack Sizes
Supplied in 50 g, 225 g, 1 Kg and 5 Kg packs. Bulk quantities above 5 Kg, and drum or sack quantities, are available on request — contact the MakeYourSkin sales desk for a quotation and lead time.
| 50 g | Pilot batches and small production runs |
|---|---|
| 225 g | Pilot batches and indie production runs |
| 1 Kg | Regular production for small and mid-size brands |
| 5 Kg | Scaled production and contract manufacturing |
Disclaimer & Caution in Use
For external cosmetic use in professionally formulated products only. This is a concentrated raw material, not a finished cosmetic, and it is not intended for undiluted application to skin, for ingestion, or for any medicinal purpose. Wear gloves and eye protection when handling, avoid raising dust with powders, and keep out of reach of children and pets. Always run a patch test on the finished formulation, and validate stability, compatibility, pH and preservative efficacy before sale. Information supplied is offered in good faith as formulation guidance and does not constitute a safety assessment, a regulatory approval or a medical claim.
Restricted or high-diligence material. Confirm your legal position in every destination market before ordering. Supplied on the understanding that the buyer holds responsibility for compliant use, permitted concentration and claim wording.
Heat-sensitive. Add at cool-down below the temperature stated on the technical data sheet; exceeding it degrades the active and can change colour and odour.
Specification
| INCI NAME | Acetyl Hexapeptide-8 (and) Water |
|---|---|
| CAS NUMBER | 616204-22-9 |
| FAMILY | Neurocosmetic peptide solution |
| ORIGIN | Global — Synthetic peptide |
| SUPPLY FORM | Liquid |
| SOLUBILITY | Water Soluble — Water-soluble. Disperse into the water phase with stirring; avoid prolonged high heat where the material is heat-sensitive. |
| TYPICAL USE LEVEL | 2–10% of the supplied solution (supplier-specified; active peptide is usually present at ppm level) |
| pH RANGE | 4.5–7.0 |
| ADD AT | Water phase, cool-down below 40 °C |
| FUNCTIONS | Expression-line positioning |
| USED IN | Eye creams, ampoules, primers |
| STORAGE | Cold-chain material. Store refrigerated at 2–8 °C, protect from light and return to refrigeration immediately after use. Do not freeze unless the technical data sheet says otherwise. |
| PACK SIZES | 50 g to 5 Kg |
| REGULATORY | Supplier composition / claims / jurisdiction review |
How to work with it
The specification's Add at row is the one to read first. Water-phase materials added to a hot oil phase are the most common reason a batch separates.
Measure the finished product, not the premix. Outside the range the activity drops away and, for some materials, the degradation route is what causes complaints.
Then work up through stability and compatibility testing. Higher is not better, and the destination market's limit may sit below your formulation ceiling.