About this material
Hexamidine Diisethionate is bis-amidine cationic antimicrobial supplied by MakeYourSkin as white to off-white powder, water soluble for professional cosmetic formulation. Sourced in the China / TCM tradition. It is valued for preservation, anti-acne and deodorant activity, substantivity to skin.
What is Hexamidine Diisethionate?
Hexamidine Diisethionate is supplied under the INCI / technical name Hexamidine Diisethionate.
It belongs to the Bis-amidine cationic antimicrobial group. The material reaches you as white to off-white powder, water soluble. RESTRICTED not banned: EU Annex V caps it at 0.1%. Highly substantive so activity persists after rinsing, which is why it works in deodorants; cationic and therefore anionic-incompatible.
Key Properties & Benefits
- Preservation
- Anti-acne and deodorant activity
- Substantivity to skin
- Supplied with full documentation — CoA, SDS and specification
Uses & Applications
Typically formulated into deodorants, blemish care, cleansers, scalp and foot care.
How to Use — Recommended Use Level
Typical use level: 0.05-0.1%. Add at the either phase, supplier-dependent. Amphiphilic. It associates with both phases and is usually added to the phase that matches the processing temperature.
Always trial the material in your own base at small scale before scaling up. Use levels are formulation starting points, not approvals.
Technical Specification
- INCI name: Hexamidine Diisethionate
- Ingredient family: Bis-amidine cationic antimicrobial
- Origin / tradition: China / TCM
- Typical form: White to off-white powder, water soluble
- Solubility: Amphiphilic
- Typical use level: 0.05-0.1%
- pH range: 4.5–7.5
- Addition phase: Either phase, supplier-dependent
- Pack sizes: 50 g; 225 g; 1 Kg; 5 Kg; bulk on request
Technical Notes
RESTRICTED not banned: EU Annex V caps it at 0.1%. Highly substantive so activity persists after rinsing, which is why it works in deodorants; cationic and therefore anionic-incompatible.
Regulatory Note
Sold as a cosmetic raw material for professional formulation. A published INCI name does not by itself authorise use: the buyer is responsible for confirming permitted status, maximum concentration, restrictions by product type, labelling and claim rules in every market the finished product is sold in. In India, cosmetics fall under the Drugs and Cosmetics Act 1940 and the Cosmetics Rules 2020 administered by CDSCO, with BIS standards (including IS 4707 Part 2) listing restricted substances. The EU applies Regulation (EC) No 1223/2009 and its Annexes; the United States applies the FD&C Act as amended by MoCRA; Korea, Japan and China operate their own positive lists and functional-cosmetic frameworks. Every finished product needs its own safety assessment.
Documentation Supplied
Certificate of Analysis (CoA) for the batch supplied; Safety Data Sheet (SDS / MSDS) in the current GHS format; INCI and technical specification sheet; allergen, GMO and origin statements on request; vegan, halal and kosher declarations where the supply chain supports them.
Available Pack Sizes
50 g; 225 g; 1 Kg; 5 Kg; bulk on request
Disclaimer & Caution in Use
For external cosmetic use in professionally formulated products only. This is a concentrated raw material, not a finished product: do not apply it undiluted to skin or hair. Wear suitable gloves and eye protection when handling, weigh in a ventilated area, and keep out of reach of children. Patch test every finished formulation. Not for ingestion unless a food or oral-care grade is specifically supplied and documented as such. Seek medical advice in case of eye contact, ingestion or an adverse reaction.
Specification
| INCI NAME | Hexamidine Diisethionate |
|---|---|
| CAS NUMBER | Not assigned |
| FAMILY | Bis-amidine cationic antimicrobial |
| ORIGIN | China / TCM |
| SUPPLY FORM | White to off-white powder, water soluble |
| SOLUBILITY | Amphiphilic. It associates with both phases and is usually added to the phase that matches the processing temperature. |
| TYPICAL USE LEVEL | 0.05-0.1% |
| pH RANGE | 4.5–7.5 |
| ADD AT | Either phase, supplier-dependent |
| FUNCTIONS | Preservation, anti-acne and deodorant activity, substantivity to skin |
| USED IN | Deodorants, blemish care, cleansers, scalp and foot care |
| STORAGE | Store at 15–25 °C in a tightly closed container, protected from light. Do not freeze. Some biological materials are supplied chilled — follow the batch documentation. |
| PACK SIZES | 50 g; 225 g; 1 Kg; 5 Kg; bulk on request |
| LEAD TIME | 10–16 days |
| REGULATORY | Sold as a cosmetic raw material for professional formulation. A published INCI name does not by itself authorise use: the buyer is responsible for confirming permitted status, maximum concentration, restrictions by product type, labelling and claim rules in every market the finished product is sold in. In India, cosmetics fall under the Drugs and Cosmetics Act 1940 and the Cosmetics Rules 2020 administered by CDSCO, with BIS standards (including IS 4707 Part 2) listing restricted substances. The EU applies Regulation (EC) No 1223/2009 and its Annexes; the United States applies the FD&C Act as amended by MoCRA; Korea, Japan and China operate their own positive lists and functional-cosmetic frameworks. Every finished product needs its own safety assessment. |
How to work with it
The specification's Add at row is the one to read first. Water-phase materials added to a hot oil phase are the most common reason a batch separates.
Measure the finished product, not the premix. Outside the range the activity drops away and, for some materials, the degradation route is what causes complaints.
Then work up through stability and compatibility testing. Higher is not better, and the destination market's limit may sit below your formulation ceiling.